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Answer to Question #57341 in Biochemistry for Sanjukta Ghosh

Question #57341
Why is Phosphofructokinase-1 reaction considered the key regulatory step in Glycolysis and not Hexokinase reaction?
Expert's answer
Both reactions are irreversible and are considered to be important in the regulation of glycolysis pathway. However, phosphofructokinase-1 reaction is the first irreversible reaction specific for glycolysis. Hexokinase reaction can take place in case of other metabolic pathways, pentose phosphate pathway for example, while phosphofructokinase-1 reaction is present only in glycolysis. Secondly, phosphofructokinase-1 is an allosteric enzyme, which has a great number of activators and inhibitors. Phosphoenolpyruvate is one of the substances produced during glycolysis and it affects the functioning of phosphofructokinase-1, not hexokinase. In the same way, AMP, ATP and citrate also regulate the activity of phosphofructokinase-1

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