Answer to Question #57341 in Biochemistry for Sanjukta Ghosh

Question #57341
Why is Phosphofructokinase-1 reaction considered the key regulatory step in Glycolysis and not Hexokinase reaction?
1
Expert's answer
2016-01-17T06:15:07-0500
Both reactions are irreversible and are considered to be important in the regulation of glycolysis pathway. However, phosphofructokinase-1 reaction is the first irreversible reaction specific for glycolysis. Hexokinase reaction can take place in case of other metabolic pathways, pentose phosphate pathway for example, while phosphofructokinase-1 reaction is present only in glycolysis. Secondly, phosphofructokinase-1 is an allosteric enzyme, which has a great number of activators and inhibitors. Phosphoenolpyruvate is one of the substances produced during glycolysis and it affects the functioning of phosphofructokinase-1, not hexokinase. In the same way, AMP, ATP and citrate also regulate the activity of phosphofructokinase-1

Need a fast expert's response?

Submit order

and get a quick answer at the best price

for any assignment or question with DETAILED EXPLANATIONS!

Comments

No comments. Be first!

Leave a comment

Ask Your question

LATEST TUTORIALS
New on Blog
APPROVED BY CLIENTS