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Answer to Question #5251 in Biochemistry for HALEY

Question #5251
What are the Major Modes/Pathways for Biotransformation and Elimination for the chemical MEK?
Expert's answer
The available evidence indicates that the metabolism of MEK is similar in humans and experimental animals. The majority of MEK is metabolized to 3-hydroxy-2-butanone, which is subsequently metabolized to 2,3-butanediol. A small portion is reversibly converted to 2-butanol

In human studies involving acute inhalation exposure, the urinary excretion of MEK and metabolites and the exhalation of unchanged MEK have been
estimated to account for only a small percentage (0.1–3%) of the absorbed
dose (Perbellini et al., 1984; Liira et al., 1988). The
remainder of the absorbed dose is expected to have undergone rapid transformation to carbon dioxide and water through intermediary metabolic pathways.

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