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Answer to Question #5082 in Biochemistry for saif

Question #5082
(6 points) Write a one or two-sentence response to the following questions/statements.
(a) In liver, glucagon stimulates glycogen breakdown via cAMP dependent signaling. Although one
might expect glucagon also to stimulate catabolism of the glucose formed (much like epinephrine
stimulates catabolism of glucose in muscle), glucagon inhibits glycolysis and stimulates
gluconeogenesis.
(b) An individual with glucose-6-phosphatase deficiency suffers from chronic hypoglycemia.
(c) 14CO2 was bubbled through a suspension of liver cells that was undergoing gluconeogenesis from
lactate to glucose. Which carbons in the glucose molecule would become radioactive
Expert's answer
a)This statement is correct. Glucagon stimulates glucose metabolism that move in the direction of its formation.
b)An individual with glucose-6-phosphatase deficiency suffers from chronic hypoglycemia because this enzyme catalyzes the formation of glucose from glucose-6-phosphate.

c)Any of the carbon in the glucose molecule will be radioactive because 14CO2 will be derived on the stage of formation of phosphoenolpyruvate.

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