Answer to Question #46319 in Biochemistry for deepu singh
The two bioactive forms of vitamin B12 (cyanocobalamin) are methylcobalamin in the cytosol and adenosylcobalamin in mitochondria. B12 methylcobalamin and 5-methyltetrahydrofolate are needed by Methionine synthase in the Methionine cycle to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine, thereby generating tetrahydrofolate and methionine, which is used to make S-adenosyl methyonine.
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