Answer to Question #249673 in Biochemistry for VANJING

Question

 In the first stage of glycolysis, fructose-1,6-bisphosphate is

cleaved to form glyceraldehyde-3-phosphate and dihydroxy-

acetone phosphate. The latter molecule can then be con-

verted to glyceraldehyde-3-phosphate. Illustrate the

mechanisms whereby these reactions occur.

Answer 1

The mechanism involves an intra-molecular oxidation-reduction where Dihydroxyacetone phosphate (DHAP) is converted to glyceraldehyde-3-phosphate by glycerol-3-phosphate dehydrogenase.