What would be the metabolic consequences of cells not expressing LDL receptors?
LDL receptors on the surface of hepatocytes are necessary for the binding and subsequent uptake of LDL molecules in the blood, a genetic decrease in LDL receptor number would cause a decreased ability of hepatocytes to absorb LDL and would increase LDL in the blood . LDL reaches the walls of the artery, where it can harden and narrow the passages in the arteries. Increased cholesterol levels lead to severe hypercholesterolemia, with ensuing accelerated development of atherosclerosis and its complications.
1. Pirahanchi Y.; Sinawe H.; Dimri M. Biochemistry, LDL Cholesterol StatPearls Publishing, Treasure Island (FL). 2020 Sep 8; 30137845 - <span style="mso-ansi-language:EN-US" lang="EN-US">PubMed </span>