Answer to Question #187446 in Biochemistry for Himansha

Question #187446

Why does blood clot inside a syringe? What is the mechanism of it?

Expert's answer

Due to chances of blood clotting before an injection is complete, all clinically-approved syringes are pre-coated with anticoagulants e.g. sodium citrate, heparin, etc., that are washed off in no more than a few injections.

Reasons and mechanisms of blood clotting

  • If a syringe was used, did it take a longer than normal time to fill the syringe? This could result in clot formation within the syringe.

  • Clots may also form when using the Vacutainer or butterfly needle systems if all tubes are not mixed by gentle inversion following collection by any method of venipuncture.

Clotting of blood is prevented by one of the following methods:

Chelation or binding of calcium.

Precipitation of calcium making it unavailable to the clotting process.

Inhibiting the formation of thronging which is needed to convert fibrinogen to fibrin in the coagulation process.

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