Answer to Question #152341 in Biochemistry for Riti

Question #152341

Write the structure and function of coenzyme form of the vitamin attached to the acyl carrier protein

Expert's answer

A prosthetic group of the acyl carrier protein is performed by phosphopantetheine; it`s structure is following:

It is involved in pathways of primary and secondary metabolism including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, and peptidyl carrier proteins and aryl carrier proteins of nonribosomal peptide synthetases. Phosphopantetheine fulfills two demands in these biosynthetic pathways. First, the intermediates remain covalently linked to the synthases (or synthetases) in an energy-rich linkage. Second, the flexibility and length of the phosphopantetheine chain (approximately 2 nm) allows the covalently tethered intermediates to have access to spatially distinct enzyme-active sites. This increases the effective molarity of the intermediate and allows an assembly line-like process.

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