Answer to Question #149657 in Biochemistry for jethro wyn elum

Question #149657
How can mutations accumulate, given that the ells have repair systems that fix changes or breaks in DNA strands?
1
Expert's answer
2020-12-10T11:24:20-0500

Cells have a variety of mechanisms to prevent mutations, or permanent changes in DNA sequence. These mechanisms include; chemical reversal, excision repair, and double-stranded break repair. However, mutations happen, and get passed on to daughter cells, only when these mechanisms fail. Cancer, in turn, develops only when multiple mutations in division-related genes accumulate in the same cell. This is a case of mutations accumulation.


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