Answer to Question #136883 in Biochemistry for Jelly

Question

At Extreme Acidity why does enzymes get denature?

Answer 1

 

Denaturing of Enzymes by the Acid          

Enzyme works at certain optimal PH.A change in the PH can alter the  ionization of amino acids group. The change in Amino acids group alters the hydrogen bonding in the protein molecules Forterre (1989). As a result, the molecules changes their shape making it ineffective lowering it activeness. This eventually denatures the enzymes.                                   

   

References

Edwin, F.; Sharma, Y.V.; Jagannadham, M.V. (2002) Stabilization of molten globule state of papain by urea. Biochemical and Biophysical Research Communication