Answer to Question #109719 in Biochemistry for kylie

Question

State which vitamin is deficient in the following scenarios?
A young man on tuberculosis treatment develops a peripheral neuropathy. A co-factor needed for transamination is deficient

Answer 1

Active form of vitamin B6, pyridoxal 5′-phosphate, serves as a coenzyme in some 100 enzyme reactions, including transamination. Isoniazid is an antituberculosis drug, but is known to cause interference with vitamin B6 metabolism, leading to the deficiency of this micronutrient and resultant peripheral neuropathy.