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Answer to Question #10065 in Biochemistry for Nkambo siragi

Question #10065
What are the possible causes of macrocyosis and how can be corrected?
Expert's answer
Common causes of macrocytosis include:Vitamin B-12 deficiency
Folate deficiency
Liver disease
AlcoholismHypothyroidismA side effect of certain medications, such as those used to treat cancer, seizures
and autoimmune disorders
Increased red blood cell production by the bone marrow (regeneration) to correct anemia,
for example, after blood loss.
Treatment of macrocytosis, if needed, is directed at the underlying cause. In the case of
vitamin B-12 or folate deficiency, for instance, treatment may include diet
modification and dietary supplements or injections. If macrocytosis is caused by
severe anemia, a blood transfusion might be necessary.

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