Long-term potentiation is a process where the chemical synapses simulates high frequency that increases the strength of the synaptic. Long-tern potentiation is one of the major cellular mechanisms underlying memory and learning. This is because the memories are normally encoded after modifying the strength of the synapse. Long-term potentiation therefore can be thought of the way in which the brain responds to experiences and hence changes. Therefore, it is a mechanisms that underlies memory and learning.