The State of Tennessee marks one of the significant regions for the Native American struggle for independence during the 17th century. The region was marked with considerable peace where the natives lived a life of freedom, able to maintain traditional practices and culture, similar to that of their ancestors. However, with the arrival of the Europeans in the 17th century, life gradually changed, with the primary cause of change being Europe’s desire for land. To them, the land was something to own. The native Americans, who were majorly the Indian Americans, devised ways to resist the influence of the Europeans. The primary method employed was resisting the efforts of the Europeans to control and encroach land during the period. However, they had to struggle full of problems that included the slave trade, diseases, and the increasing European population. The resistance to control use the use of land involved diplomacy, alliances, and even warfare with the Europeans. Thus, the century is termed as the era of ‘New World’ where various leaders had to form alliances with Native Americans in Tennessee when the European nations were scrambling to claim the already occupied productive land.