However, I have gradually adjusted myself __to____ town life.
To or with
The correct preposition is “to.” The preposition “with” is used when describing two aspects that act or exist together. Therefore, it does not fit in the named sentence since the pronoun “myself” and the noun “town life” exist independently. Comparatively, “to” is used when describing one thing that acts on another. This preposition fits in the blank space as it shows that the person in “myself” is the one adjusting to “town life.”