Sickle cell anemia (Sickle cell anemia) is an inherited recessive blood disorder characterized by chronic hemoglobin anemia, the sixth amino acid of the β chain of hemoglobin (glutamic acid) being Substituted by valine. This disease is common in populations whose ancestors come from sub-Saharan Africa. In an individual, the presence of two ss alleles gives the disease. An Ace individual is a carrier and an AA individual is normal. If 9% of the African population comes into the world with this disease (ss), calculates the percentage of the population that would carry the disease or As heterozygotes.
The frequency of ss genotype is 9% / 100 % = 0.09 Thus, the frequency of s allele is square root of 0.09, which is 0.3 The frequency of A allele is 1 - 0.3=0.7 The frequency of As genotype is 2 * 0.3 * 0.7 = 0.42 Thus, 42% of population are carriers
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