1. Answer the questions below (a-c) for the follow series of compounds:
a. Which compound above is MOST acidic?
b. Which compound above is LEAST acidic?
c. Which compound above is MOST susceptible to hydrolysis?
COOH is the most acidic
OH least acidic
Esters and amides are the most commonly encountered groups in drugs that are susceptible to hydrolysis. However, a large number of other functional groups can also react with water, resulting in broken bonds.