Answer to Question #39096 in Microbiology for casey
Amphotericin B from Streptomyces spp. binds to the sterols in fungal membranes, disrupting membrane permeability and causing leakage of cell constituents. Mammalian and fungal membranes both contain sterols. Therefore amphotericin B molecules can form pores in the host membrane as well as the fungal membrane. Thus, amphotericin B is quite toxic and used only for serious, life-threatening infections.
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