Answer to Question #40358 in Biochemistry for Ashay Arun Patil

Question #40358
Why is the first enzyme in TCA cycle called citrate synthase and not citrate synthetase?
1
Expert's answer
2014-03-24T11:04:04-0400
Citrate synthase catalyzes the condensation reaction of the acetate residue from acetyl coenzyme A and a molecule of oxaloacetate to form the citrate. However, no ATP is used in this reaction. Synthetases use ATP by definition, therefore, this enzyme is a synthase

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