Answer to Question #116189 in Biochemistry for Annie spark

Question #116189
Are the reactions pyruvate to ethanol and pyruvate to lactate both reversible. If not, why not?
1
Expert's answer
2020-05-21T09:27:05-0400

The pyruvate → lactate reaction is reversible, but the pyruvate → ethanol reaction is irreversible.

In homolactic fermentation, pyruvate is reversibly reduced to lactate o regenerate NAD+. In alcoholic fermentation, pyruvate is decarboxylated by a thiamine pyrophosphate (TPP)–dependent mechanism, to yield CO2 and acetaldehyde, which is then reduced by NADH to yield NAD+ and ethanol.  


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