Answer to Question #47820 in Microbiology for Samira

Question #47820
During the process of Protein synthesis, what are the protein modifications that take place in the Rough Endoplasmic Reticulum and the Golgi?
1
Expert's answer
2014-10-14T12:44:11-0400
There are following main events which occur with newly synthesized polypeptides in RER: formation of disulfide bonds, protein folding, glycosylation (addition of carbohydrates), and assembly of polypeptides chains. Some of these processes, like glycosylation, phosphorylation, adding of manose-6-phosphate to the proteins, occur in Golgi apparatus. In the Golgi apparatus also takes place the process of proteolytic cleavage of large proteins to small active proteins by specific endoproteases.

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